This medicine comes with a Patient Information Leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after food), usually 3 times daily or as directed by your doctor. If indinavir causes an upset stomach, you may take it with non-fat milk, juice (except grapefruit), dry toast with jelly (no butter), or corn flakes with non-fat milk and sugar. The dosage is based on your weight, liver function, medical condition, other medications, and response to therapy. It is very important to continue taking this medication (and other HIV medications) exactly as prescribed by your doctor. This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day. Do not take more or less of this drug than prescribed or stop taking it (or other HIV medicines) even for a short time unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat (resistant), or worsen side effects.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. This drug should not be used with the following medications because very serious interactions may occur: amiodarone, alprazolam, rifampin, cisapride, pimozide, dihydroergotamine, ergonovine, ergotamine, methylergonovine, St John's wort, lovastatin, simvastatin, midazolam, triazolam, eletriptan, atazanavir, conivaptan, ranolazine. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: garlic capsules, sildenafil, tadalafil, vardenafil, trazodone, venlafaxine, itraconazole, ketoconazole, drugs for diabetes (e.g., glyburide, insulins), efavirenz, ritonavir, lopinavir, saquinavir, delavirdine, nevirapine, nelfinavir, didanosine, carbamazepine, phenobarbital, phenytoin, rifabutin, atorvastatin, bepridil, lidocaine, quinidine, certain calcium channel blockers (e.g., nifedipine, felodipine, nicardipine), clarithromycin, fluticasone nasal, cyclosporine, tacrolimus, sirolimus, sunitinib. If any of these medications are taken with indinavir, your doctor may change your dose of indinavir or the other drug(s), or your doctor may monitor you specially. Consult your doctor or pharmacist for more details.


MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).


To reduce the risk of spreading HIV to others, always use effective barrier protections (e.g., latex or polyurethane condoms, dental dams) during all sexual activity. Consult your doctor or pharmacist for more details. Do not share this medication with others. Laboratory and/or medical tests (e.g., liver tests, viral load, t-cell counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. Keep all medical and laboratory appointments.


If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.


Before taking indinavir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis with other HIV medicines, liver problems (e.g., hepatitis B, hepatitis C), alcohol use, diabetes, hemophilia, kidney stones, high blood fats (high cholesterol/triglycerides). If you have diabetes, this product may increase your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar, such as increased thirst and urination. Your anti-diabetic medication or diet may need to be adjusted. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To help decrease the risk of kidney problems while taking indinavir, drink at least 6 full glasses (8 ounces each) of water throughout the day. This medication should be used only when clearly needed during pregnancy. However, it is now normal to prescribe HIV medicines for pregnant women with HIV. This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.


Store indinavir capsules at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.


See also Warning section. Stomach pain, nausea, vomiting, heartburn, loss of appetite, headache, strange taste in the mouth, dry skin, or fever may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Since indinavir can cause kidney stones, tell your doctor immediately if you have side or mid-back pain, pink/bloody urine, or pain with urination. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression), problems sleeping, sleepiness, dizziness, tingling/numbness of hands or feet, joint pain, mouth ulcers, decreased sexual ability, muscle weakness/cramps/aches, increasing tiredness, increased urination (especially at night), increased thirst, hair loss, darkening skin color, decrease in the amount of urine, persistent nausea, abdominal/stomach pain, dark urine, yellowing eyes/skin. Tell your doctor immediately if any of these rare but very serious side effects occur: stomach/back pain with or without nausea/vomiting, chills, persistent sore throat, easy bruising/bleeding, persistent nausea, stomach/abdominal pain, dark urine, yellowing eyes/skin, severe tiredness, fainting, pale lips/nails/skin, fast/irregular heartbeat, fast breathing, chest pain, unusual sweating. Changes in body fat may occur while you are taking this medication (e.g., increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exercise to reduce this side effect. If you are taking HIV medications for the first time, you may experience symptoms of an old infection. This may happen as your immune system begins to work better. Symptoms may include: new cough, trouble breathing, fever, new vision problems, new headaches, new skin problems. Contact your doctor immediately if you should have any of these effects. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


This drug is used in combination with at least 2 other medications to help control your HIV infection, thereby improving your quality of life. It also lowers your risk of getting HIV complications (e.g., new infections, cancer). Indinavir belongs to a class of drugs known as protease inhibitors. Indinavir is not a cure for HIV and it does not prevent the spread of HIV to others through sexual contact or blood contamination (e.g., sharing used needles).


This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to prevent HIV infection after contact with the virus.


Indinavir is known to interact with many different types of medicines, in some cases causing severe (sometimes fatal) reactions. Consult your doctor or pharmacist about which medications should not be taken with indinavir. (See also Drug Interactions section.)


If you miss a dose, take it as soon as you remember unless it is less than 2 hours before the time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product is safe, effective, or appropriate for you.